https://www.ncbi.nlm.nih.gov/pubmed/28479483
Autoimmun Rev. 2017 Jul;16(7):712-721. doi: 10.1016/j.autrev.2017.05.007. Epub 2017 May 4.
Coffee and autoimmunity: More than a mere hot beverage!
Abstract
Coffee
is one of the world's most consumed beverage. In the last decades,
coffee consumption has attracted a huge body of research due to its
impact on health. Recent scientific evidences showed that coffee intake
could be associated with decreased mortality from cardiovascular and
neurological diseases, diabetes type II, as well as from endometrial and
liver cancer, among others. In this review, on the basis of available
data in the literature, we aimed to investigate the association between
coffee intake and its influence on the immune system and the insurgence
of the most relevant autoimmune diseases. While some studies reported
conflicting results, general trends have been identified. Coffee
consumption seems to increase the risk of developing rheumatoid
arthritis (RA) and type 1 diabetes mellitus (T1DM). By contrast, coffee
consumption may exert a protective role against multiple sclerosis,
primary sclerosing cholangitis, and ulcerative colitis. Concerning other
autoimmune diseases such as systemic lupus erythematosus, psoriasis,
primary biliary cholangitis and Crohn's disease, no significant
association was found. In other studies, coffee consumption was shown to
influence disease course and management options. Coffee intake led to a
decrease in insulin sensitivity in T1DM, in methotrexate efficacy in
RA, and in levothyroxine absorption in Hashimoto's disease. Further,
coffee consumption was associated with cross reactivity with gliadin
antibodies in celiac patients. Data on certain autoimmune diseases like
systemic sclerosis, Sjögren's syndrome, and Behçet's disease, among
others, are lacking in the existent literature. As such, further
research is warranted.
KEYWORDS:
Autoimmune diseases; Autoimmunity; Caffeine; Clinical nutrition; Coffee; Rheumatoid arthritis; Rheumatology