Eur J Pediatr. 2011 Dec;170(12):1597-602. doi: 10.1007/s00431-011-1568-5. Epub 2011 Sep 23.
Lane-Hamilton syndrome: case report and review of the literature.
Abstract
We
report a case of a three-and-a-half-year-old boy, who presented with
poor general condition, stunted growth, had the presence of nail
clubbing, persistent cough and frequent diarrhoea. Persistent iron
deficiency anaemia without signs of haemolysis suggested Lane-Hamilton
syndrome (LHS) which is or/is an extremely rare combination of
idiopathic pulmonary haemosiderosis (IPH) and celiac disease (CD),
although both diseases are immunologically mediated and the pathogenetic
link between them is not clear. We have now 3 years of follow-up on
gluten-free diet (GFD), resulting in a gradual recovery of the abnormal
laboratory results in combination with an improving growth. Clinically,
he is asymptomatic without any additional treatment. Our case
illustrates that CD should be specifically looked for in patients with
IPH, especially those in whom the severity of anaemia is
disproportionate to the IPH symptoms. Both diseases may benefit from a
GFD.
- PMID:
- 21947219
- DOI:
- 10.1007/s00431-011-1568-5
- [Indexed for MEDLINE]
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