Uusinta tutkimusta UBD(FAT10) ubikitiinin kaltaisesta modifikaattorista onkogeenina

 https://pubmed.ncbi.nlm.nih.gov/41430299/

. 2025 Dec 22;23(1):532.

 doi: 10.1186/s12964-025-02513-4.

Multi-omics reveals FAT10 as an immunometabolic survival factor rewiring global metabolism in cancer

Jun Yan Loh 1 2 3, Jianhong Ching 4 5, Jean-Paul Kovalik 4, Shuaichen Liu 1, Lee Jin Lim 1, Samuel S Chong 2 6, Caroline G L Lee 7 8 9 10

Affiliations 

• PMID: 41430299
 
• PMCID: PMC12723956
 
• DOI: 10.1186/s12964-025-02513-4

Abstract

Background: FAT10 is an inflammation-induced oncogene highly overexpressed across multiple cancers. As a ubiquitin-like protein, it regulates interacting proteins by destabilizing, stabilizing or delocalizing them. Despite its extensive influence on targets from various cellular pathways, prior studies largely focused on interrogating individual protein interactions, limiting our understanding of FAT10’s broader oncogenic role.