Peptidaasit keliakiapotilaan suolinukassa taudin akuutissa ja remissiovaiheessa

Clin Chim Acta. 1981 Jan 8;109(1):53-8. Intestinal peptidases and sucrase in coeliac disease.

Sjöström H, Norén O, Krasilnikoff PA, Gudmand-Høyer E.

Abstract

The activities of microvillus
aminopeptidase (microsomal, EC 3.4.11.2),
 dipeptidyl peptidase IV (EC 3.4.14.-),
 glycyl-leucine dipeptidase (EC 3.4.13.11),
proline dipeptidase (EC 3.4.13.9),
 sucrase (EC 3.2.1.48) and
 gamma-glutamyl transpeptidase (EC 2.3.2.2)
were measured in peroral intestinal biopsies taken from patients with coeliac disease in the acute phase and in remission. A comparison with the amounts of corresponding activities from a reference group showed that all the measured activities were significantly decreased in the acute phase of the disease.

 In patients in remission only microvillus
 aminopeptidase and
dipeptidyl dipeptidase IV displayed a substantial depression
 as compared to the reference group.

It is suggested that a primary mucosal digestion defect will result in lack of substrate for other intestinal enzymes. This is a situation comparable to starvation and may explain the variation in the grade of restitution for the different enzymes.

PMID:

7008982

[PubMed - indexed for MEDLINE]

1996 Free paper Abstracts. Oats and other cereals. A126- A138

A126 Fiveryear follow-up study: use of oats and adherence to gluten-free diet. ( Kuopio, Finland)

A127.Oats for patients with dermatitis herpetiformis. (Tamper, Helsinki, Finland)

A128.  Oats in coeliac diet;  A five year follow up study. (Kuopio,. Finland)

A129.  Adult patients with coeliac disease have no antigliadin or antireticulin antibody response to oats.  (Kuopio,, Finland)

A130. The oat - celiac study in Gothenburg (Göteborg, Sweden)

A131.  Effect of heat treatment on solubility of oat proteins (Tallinn, Estland)

A132.  Contamination of rolled oats with wheat, barley and rye. (The Netherlands)

A133.  Oats and gliadin (Berne, Switzerland)

A134. Oats prolamines in vitro activate intestinal cell-mediated immunity in coeliac disease (Rome, Italy)

A135 A small ppeptide from durum wheat prevents cell agglutination induced by cereal prolamin (Rome, Italy)

A136.  MALDI-TOF mass spectrometry as a new tool to detect gliadins in food. (Madrid,. Spain)

A137. Gluten in gluten-free products (Uppsala, Sweden)

A138. Application of PCD methodology to detect wheat DNA in foodstuffs. (Budapest,, Hungary)

1996 Free paper Abstracts. Pathogenesis, immunology and genetics. A139-A181

A139. Purified coeliac disease patient serum IgA inhibits fibroblast and TGF-beta induced epithelial cell (T84) differentiation in vitro. (Tampere, Finland)

A140.  Nitric oxide does not play a role in the initial mucosal response to the instillation of gluten into the rectum (Buenos Aires, Argentina)

A141,  INOS expression in coeliac disease small-bovel biopsy tissue (Maastricht, the Netherlands)

A142. Increased urinary nitric oxide (NO) oxidation  products in children with active coeliac disease (Maastricht, the Netherlands)

A143.  Children with coeliac disease express iNOS in the small intestine epithelium (Norrköping,  Sweden)
http://serials.unibo.it/cgi-ser/start/it/spogli/ds-s.tcl?authors=%22PETERSON+KH%22&language=ITALIANO

A144.  Gluten stimulates NO production in children with coelic disease? (Norrköping, Sweden)

A145. Reduced Na+K+ Pump activity in the erythrocytes of children with treated coeliac disease (Budapest, Hungary)
 http://journals.lww.com/jpgn/fulltext/1996/05000/43_decreased_na__k_atpase_activity_and_increased.56.aspx

A146.Changes in the expression of transcripts of the calcium-binding protein calbindin-D9K in duodenal biopsies in coeliac disease. (London, UK)

A147.  The organe culture of human intestinal biopsies as an in vitro-model for coeliac disease in remission. (Düsseldorf, Germany)

A148.  Integrins and coeliac disease.Pittschieler K, Ladinser B.
 (Italy) http://journals.lww.com/jpgn/fulltext/1996/05000/35_integrins_and_coeliac_disease.48.aspx

A149. Distinct distribution of sulphated glycosaminoglycans within coeliac mucosa, Simon Murch, Alan Phillips  (London, UK)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157760/

A150.  Enhanced gliadin peptide binding to intact small intestinal brush border membranes in coeliac disease. (Tübingen, Germany)

A151.  Diversity of epitopes of coeliac disease autoantibodies (Leipzig, Germany)

A152. Studies on IgA-autoantibodies against fibroblast derived antigens in celiac disease (Uppsala, Sweden)

A153. Ig-A antibodies against human proteins in sera from coeliac patients determined by western blotting (uppsala, Sweden)

A154. Cross-reactivity of antigliadin antibodies in coeliac patients with enterocyte antigens (Edmonton, Canada) http://www.ncbi.nlm.nih.gov/pubmed/9400629
 Vasta-aineita kalretikuliinia kohtaan.  ( Tässä sivuhyppu. katsoin akertuuko kalretikuliini APP, Abeeta asioihinja se tarkertuu. Musiiin Mmeoryblogiin  "Calretikuliini".

A155. Deficit  in spontaneous IL-4 secretion by intraepithelial and laminapropria (LPL) lymphcytes from adult coeliac patients.  (France) In conclusion: a defect of IL-4 secretion by intestinal lymphocytes could represent a primary immune dysfunction in adult coeliac disease.

A156. Cytokine production following gliadin stimulation of circulateing peripheral blood mononuclear cells (Maynooth, ireland)

A157. Soluble interleukin-2 (SIL-2R) receptor concentration in serum or children with coeliac disease before and after introduction of a gluten-free diet. (sIL-2R concentration coul be used as an additional method in the coeliac patient therapy response evaluation)

A158.  Leukocyte aggregation and celiac disease. (Milan italy)
http://www.enabling.org/ia/celiac/tamper.htmlhttp://www.enabling.org/ia/celiac/tamper.html

A159.IFN-gamma and IL-4 producin cells in blood of children with coeliac disease.(Uppsala, Sweden)

A160. Effect of alfa-gliadin on intestinal epithelial cell lines; a comparison with G+ and G- antigens( Paris, France)

A161  Gliadin specific, CD4+ T cells are frequntly found in the small intestinal mucosa of both celiac disease and dermatitis herpetiformis patients.  (Oslo, Norway)

A162  Cellular immunity in coeliac disease  (Thessaloniki, Greece)

A163.  Specificity to cereal prolamines an HLA restriction of the T-cell clones isolated from jejunal mucosa of celiac patients.

A164.  T-cell receptor (TCR) repertoire in coeliac disease (CD) conserved junctional sequences in the untreated mucosa (Naples, Italy)

A165. T-lymphocyte sub-populations in healthy human intestinal lamina propria. (Dublin, Ireland)

A166 Quantification of intraepithelial lymphocytes (IEL) subsets by flow cytometry analysis (FCA).

A167. Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation. (Dublin, Ireland)

A168. Quantification of intraepithelial lymphocytes using computerised image analysis.

A169. Intraepithelial  lymphocytes (IELs) in the celiac mucosa induce cell death (apoptosis) of enterocytes (Jerusalem, israel)

A170. T cell immune responses to gliadin in coeliac and normal individuals (Ireland)

A171. Immune response in vitro to human fibroblast-derived coeliac disease autoantigen is HLA DR/DQ restricted (Hki, Tre, Finalnd)

A172. Circulating CD45RO+ TcR gammadelta cells in coeliac disease  patients and their healthy family members ( Hki, Tre, Finland)

A173. HLA-DQ2 as a marker of potential coeliac disease among first-degree relatives of coeliac patients 8Spain)

A174.  Relationship between abnormal immunological parameters and the coeliac HLA haplotype in non-coeliac patients. (Edinburgh)

A175. TNF2, a polymorfism of the TNF.-alfa promoter,  is a component of the coeliac disease haplotype.

A176. Restricted T-cell receptor Vbeta gene usage in the skin of patients with dermatitis herpetiformis(DH) . Conclusion: These results support the hypothesis that recognition of an antigen or superantigen is involved in the pathogenesis of DH skin lesions.

A177. Gliadin-induced enteropathy in rats affects activities of intestinal brush-border enzymes (Czech Republic)
Conclusion: Rat model of intestinal enteropathy revealed that alfa-glukosidases increased while lactase, dipeptidylpeptidase (DPP IV)  and  gamma-glutamyltranspeptidase (GGT) decreased after gliadin feeding to newbornd animals.

A178. Experimental model of coeliac disease in non-suckling, artificially fed rats. (Czech republic)

A179. DLA-DQ alleles in Irish setter dogs with naturally occuring gluten-sensitive enteropathy (London, UK)
 
A180. Jejunal leucocyte populations in the early stages of gluten sensitive enteropathy in Irish setter dogs. (London, UK) 

A181. Lamina propria and intraepithelial leucocyte populations in Irish setter dogs with gluten sensitive enteropathy. (London, UK)

1996 Free Paper Abstracts. A98- A125 Serology.

A98.  Screening relatives of patients with coeliac disedase by means of serum anti-endomysium antibodies .

A99  Human umbilical vein endthelial cells: a new easily available substrate for detecting endomysial antibodies in patients with coeliac disease (Dublin)

A100. Antiednomysium antibody on human umbilical cord vein: a cheap and sensitive diagnostic tool for the screening of celiac disease (Trieste, Italy)

A101.  Evaluation of the endomysiual antibody test in screening for coeliac disease: in a clinical practice setting.  (Dublin)

A102. Human umbilical cord tissue: a suitable substrate for endomysial antibody detection. (UK)

A103. Endomysium autoantibodies on human umbilical cord (HUC) in coeliac disease (Finland)

A104.  Human umbilical cord-derived fibroblasts as antigen in whole cell Elisa for coeliac disease antibodies (Finland)

A105. Connective tissue substrates in serum screening for coeliac disedase (CD).(Tübingen, Germany)

A106. Same substrate for antiendomysium, anti-jejunum and anti-reticulin assay. (Budapest,Hungary)

A107. Endomysium antibodies (EmA) and detection of silent coeliac disease (Barcelona, Spain)

A108.  Human umbilical cord antibodies (HUC-Ab) for CD-screening (Barcelona, spain)

A109 Endomysial antibodies in relation n to celiac disease (CB) activity in lamina propria of jejunal mucosa. (Prague)

A110. Frequency of aspecific staining in the anti-endomysium antibody assay (Budapest, Hungary)

A111.  Improving methods in serum screening for coeliac disease (Tübingen,Germany)

A112. Human liver- suitable antigen for reticulin antibody determination, a prospective study. (Czech Republic)

A113. Three immunological markers may replace intestinal biopsy in the diagnostic approach of coeliac disease (AGA, EMA, ARA)  (Thessaloniki, Greece)

A114. Chronic liver disease may be a cause of false positive anti-endomysium antibody assay. (Scotland, UK)

A115. Screening for coeliac disease with Pharmacia CAP system for detectin anti-gliadin IgG and IgA. (Uppsala, Sweden)

A116.  Dietary intake and false positivity of coeliac disease associated antibodies.(Belfast,  N-Ireland)

A117. UniCAP Gliadin IgA and IgG. New in vitro test system for diagnosis and monitoring of coeliac disease (Uppsala, Sweden)

A118.  The differential diagnosis of coeiac disease and other malabsorption syndromes: IgAEmA and IgGEmA tests (Warsaw, Poland)

A119. Screening tests for coeliac disease using antiendomysium antibody on human umbilical cord section (Budapest, Hungary)

A120. Serological methods for antigliadin antibody (AGA) testing: Secalins as an alternative to gliadins. (Madrid, Spain)

A121. Evaluation of the first quantitative method for the measurement of serum anti-gliadin antibodies (AGA)(Valencia, Spain)

A122. Lack of IgG-type serum anti-endomysium and anti-jejunum antibodies in dermatitis herpetiformis patients. (Budapest, Hungary)

A123. Anti-gliadin antibody producing cells in blood of children with coeliac  disease. (Uppsala, Sweden)

A124. Human  umbilical cord tissue (HUCT) : Substrate for the detection of endomysial antibodies (Dublin, Ireland)

A125.  Screening for coeliac disease among 15- and 16- years old adolescents with gliadin- and endomysial antibodies (Göteborg, Sweden) 

1996 Free Paper Abstracts.Intestinal permeability. A93- A97

A93. Intestinal permeability tests in screening of the general population for coeliac disease (Belfast)

A94.Gut permeability in adults with clinial and silent celiac disease (Sweden)

A95. Lactulose-mannitol test, antigliadin and antireticulin antibodies in the screening for coeliac disease (Finland) 

A96. Intestinal sucrose permeability in celiac disease(CD). Alberta Canada.

A97. A transcellular permeability marker is more efficient than a paracellular one in detecting coeliac disease (Sweden)

1996 Fre Paper Abstracts. Casew reports A87- A92

A87
RHABDOMYOSARCOMA OF THE BILIARY TRACT AND COELIAC DISEASE(CD) (Italy)

A88
CELIAC DISEASE IN ASSOCIATION WITH EOSINOPHILIC GRANULOMA (Uruguay)

A89
ASSOCIATION BETWEEN COELIAC DISEASE AND MULTIPLE SCLEROSIS

A90
TWO CASES OF MELKERSSON-ROSENTHAL SYNDROME ASSOCIATED WITH DERMATITIS HERPETIFORMIS AND GLUTEN SENSITIVE ENTEROPATHY  (Hungary)

A91
TRANSIENT ERYTHROBLASTOPENIA OF CHILDHOOD (TEC) AND COELIAC DISEASE: A CASE REPORT  (ITaly)

A92
PERIPHERAL NEUROPATHY ASSOCIATED WITH COELIAC DISEASE: A CASE REPORT IN A CHILD (Italy) 

1996 Free paper Abstracts. Other associated diseases and complications. A76- A86

A76
OBSTETRIC AND GYNAECOLOGICXAL PROBLEMS AND COELIAC DISEASE (Italy)
Pregnancy may precipitate coeliac disease in some women in whom the disease has not been yet diagnostised

A77
GLUTEN SENSITIVITY: EXPLORING THE NEUROLOGICAL ICEBERG (UK)
Antigliadin antibodies may directly or indirectly be involved. if elimination of these antibodies by a gluten-free diet results in stabilisation or even improvement of the neurological dysfunction,  then the role of the  duodenal biopsy becomes questionable. 

A78
NERVOUS SYSTEM MANIFESTATION IN PATIENTS WITH COELIAC DISEASE 8Finalnd)
Neurological disorders are common in patients with coeliac disease. Patients with neurological symptoms can have atypical coeliac disedase.

A79
COELIAC DISEASE AND EPILEPSY?  (Lithuania) 

A80
DOWN SYNDROME AND COELIAC DISEASE  THE PREVALENCE OF IgA-AGA  AND  IgA-EmA.   (SWEDEN)

A81
ANTI_GLIADIN AND ANTI_ENDOMYSIUM ANTIBODIES IN CHILDREN WITH DOWNS SYNDROME  (Sweden)

A82
CELIAC DISEASE IN WLLIAMS SYNDROME (Italy)


A83
COELIAC DISEASE IN PATIENTS WITH ORAL MUCOSAL SYMPTOMS (Finland)
(Patients with aphtous ulceration  and longlasting oral mucosal  symptoms   screened) 

A84
ORAL MUCOSAL CHANGES IN PATIENTS WITH COELIAC DISEASE (Finland)
(Aphtous ulcers, atrophy of the epithelium, moderate to severe inflammation;  persistent oral mucosal changes , especially ulcers  screened )
 
A85
ORAL MUCOSA IS FREQUENTLY AFFECTED IN PATIENTS  WITH DERMATITIS HERPETIFORMIS (DH)  (Finland)
Oral mucosal changes are frequent in DH, even in patients with a strict GFD. oral manifestations might even be an early sign of undiagnosed DH or DH complicated with CD.

A86
INTRAEPITHELIAL LYMPHOCYTES (IEL) BEARING GAMMA/DELTA TcR  IN THE ORAL AND JEJUNAL MUCOSA OF PATIENTS WITH DERMATITIS HERPETIFORMIS (DH)(Finland)
( Not related to gluten ingestion, because their numbers were similar in the untreated and GFD-treated DH patients)