https://www.ncbi.nlm.nih.gov/pubmed/29601440
CONCLUSIONS:
We
have sucessfully employed a conserved extended haplotype-matching
strategy and identified a novel additional celiac disease risk variant
in the lncRNA HGC14. This lncRNA seems to regulate the expression of
NOD1 in an allele-specific manner. Further functional studies are needed
to clarify the role of HCG14 in the regulation of gene expression and
to determine the molecular mechanisms by which the risk variant in HCG14
contributes to celiac disease pathogenesis.
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