J Pediatr Gastroenterol Nutr. Author manuscript; available in PMC 2018 Feb 1.
Published in final edited form as:
Intestinal Organoids: New frontiers in the study of intestinal disease and physiology
Abstract
The
development of sustainable intestinal organoid cell culture has emerged
as a new modality for the study of intestinal function and cellular
processes. Organoid culture is providing a new test-bed for therapeutic
research and development. Intestinal organoids, self-renewing
three-dimensional structures comprised of intestinal stem cells and
their differentiated epithelial progeny allow for more facile and robust
exploration of cellular activity, cell organization and structure,
genetic manipulation, and vastly more physiologic modeling of intestinal
response to stimuli as compared to traditional two dimensional cell
line cultures. Intestinal organoids are impacting a wide variety of
research into gastrointestinal pathology. The purpose of this review is
to discuss the current state-of-the-art and future impact of research
using enteroids and colonoids (organoids grown from the small and large
intestines respectively).
Keywords: Enteroid, Colonoid, lgr5, intestinal stem cell, Mini-gut, intestinal organoid, ex vivo, gut, precision medicine
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