Clin Chim Acta. 1981 Jan 8;109(1):53-8. Intestinal peptidases and sucrase in coeliac disease.
Abstract
The
activities of microvillus
aminopeptidase (microsomal, EC 3.4.11.2),
dipeptidyl peptidase IV (EC 3.4.14.-),
glycyl-leucine dipeptidase (EC 3.4.13.11),
proline dipeptidase (EC 3.4.13.9),
sucrase (EC 3.2.1.48) and
gamma-glutamyl transpeptidase (EC 2.3.2.2)
were measured in peroral intestinal biopsies taken from patients with coeliac disease in the acute phase and in remission. A comparison with the amounts of corresponding activities from a reference group showed that all the measured activities were significantly decreased in the acute phase of the disease.
In patients in remission only microvillus
aminopeptidase and
dipeptidyl dipeptidase IV displayed a substantial depression
as compared to the reference group.
It is suggested that a primary mucosal digestion defect will result in lack of substrate for other intestinal enzymes. This is a situation comparable to starvation and may explain the variation in the grade of restitution for the different enzymes.
aminopeptidase (microsomal, EC 3.4.11.2),
dipeptidyl peptidase IV (EC 3.4.14.-),
glycyl-leucine dipeptidase (EC 3.4.13.11),
proline dipeptidase (EC 3.4.13.9),
sucrase (EC 3.2.1.48) and
gamma-glutamyl transpeptidase (EC 2.3.2.2)
were measured in peroral intestinal biopsies taken from patients with coeliac disease in the acute phase and in remission. A comparison with the amounts of corresponding activities from a reference group showed that all the measured activities were significantly decreased in the acute phase of the disease.
In patients in remission only microvillus
aminopeptidase and
dipeptidyl dipeptidase IV displayed a substantial depression
as compared to the reference group.
It is suggested that a primary mucosal digestion defect will result in lack of substrate for other intestinal enzymes. This is a situation comparable to starvation and may explain the variation in the grade of restitution for the different enzymes.
- PMID:
- 7008982
- [PubMed - indexed for MEDLINE]
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