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fredag 5 juni 2015

Peptidaasit keliakiapotilaan suolinukassa taudin akuutissa ja remissiovaiheessa

Clin Chim Acta. 1981 Jan 8;109(1):53-8. Intestinal peptidases and sucrase in coeliac disease.


The activities of microvillus
aminopeptidase (microsomal, EC,
 dipeptidyl peptidase IV (EC 3.4.14.-),
 glycyl-leucine dipeptidase (EC,
proline dipeptidase (EC,
 sucrase (EC and
 gamma-glutamyl transpeptidase (EC
were measured in peroral intestinal biopsies taken from patients with coeliac disease in the acute phase and in remission. A comparison with the amounts of corresponding activities from a reference group showed that all the measured activities were significantly decreased in the acute phase of the disease.

 In patients in remission only microvillus
 aminopeptidase and
dipeptidyl dipeptidase IV displayed a substantial depression
 as compared to the reference group.

It is suggested that a primary mucosal digestion defect will result in lack of substrate for other intestinal enzymes. This is a situation comparable to starvation and may explain the variation in the grade of restitution for the different enzymes.
[PubMed - indexed for MEDLINE]

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